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Biological Properties of Citrus Flavonoids Pertaining to Cancer and Inflammation

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Citrus flavonoids encompass a diverse set of structures, including numerous flavanone and flavone O- and C-glycosides and methoxylated flavones. Each of these groups of compounds exhibits a number of in vitro and in vivo anti-inflammatory and anticancer actions. These biological properties are consistent with their effects on the microvascular endothelial tissue. Evidence suggests that the biological actions of the citrus flavonoids are possibly linked to their interactions with key regulatory enzymes involved in cell activation and receptor binding. The citrus flavonoids show little effect on normal, healthy cells, and thus typically exhibit remarkably low toxicity in animals. The citrus flavonoids extend their influence in vivo through their induction of hepatic phase I and II enzymes, and through the biological actions of their metabolites. Evidence clearly indicates to the potential health promoting properties of these dietary compounds.

Keywords: ATP Binding Sites; Anti cancer properties; Arachidonic Acid Metabolism; Cancer cell proliferation; Cell Adhesion; Citrus Flavonoids; Citrus Reticulata; Hepatic Enzyme induction; Hesperdine and Diosmin; Mechanistic Studies; Microvascular Hyperpermeability; Multidrug Resistance; Non stimulated lymphocytes; Polymethoxyflavones; Vitamin P

Document Type: Review Article

Publication date: February 1, 2001

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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