Skip to main content
padlock icon - secure page this page is secure

Microbes, Immunity and Multiple Sclerosis: An Update

Buy Article:

$68.00 + tax (Refund Policy)

Multiple Sclerosis (MS) is a heterogeneous disease of unknown etiology. The current hypothesis proposes a complex interplay between an environmental agent and the immune system that induces an abnormal response in genetically predisposed persons, leading to the autoimmune disease of MS. In recent decades the incidence and prevalence of MS seem to have increased, which may be better explained by environmental rather than genetic changes. Some infectious agents have been implicated as the possible culprits, as they could be involved in the appearance of autoreactive T cells against myelin using different mechanisms. Among microorganisms, certain bacteria, such as Chlamydia (Chlamydophila) pneumoniae have been suggested, but viruses have generally been associated with MS etiopathogenesis, with human herpesvirus 6 (HHV-6) and Epstein-Barr virus (EBV) being the best studied in recent years. Updating a previous review, we reanalyze the role of these microorganisms in MS etiology in detail and discuss the contributions of the hygiene hypothesis and environmental agents, both infectious and non-infectious, in the explanation of epidemiological changes in MS.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: EBV; HHV-6; hygiene hypothesis; immunity; microbes; multiple sclerosis

Document Type: Research Article

Publication date: February 1, 2013

More about this publication?
  • Current Immunology Reviews publishes frontier reviews on all the latest advances in clinical immunology. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in clinical immunology.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more