Skip to main content
padlock icon - secure page this page is secure

Open Access Autoimmune Diseases and Atherosclerosis: The Inflammatory Connection

Download Article:
(PDF 283.3 kb)
Atherosclerosis is a chronic inflammatory disease that contributes to majority of cardiovascular morbidity and mortality in the world. Immune system is involved in atherogenesis and disease pathogenesis. Several studies have suggested a pivotal role for immune response to autoantigens, particularly oxidized lipoproteins and heat shock proteins, in the development of the disease. Several autoimmune disorders such as inflammatory bowel disease (IBD), rheumatoid arthritis, psoriasis, diabetes type1, multiple sclerosis, chronic obstructive pulmonary disease (COPD) and systemic lupus erythematosus (SLE) have an increased association with atherosclerosis leading to higher cardiovascular mortality rates. Inflammation is a crucial link in the development of atherosclerosis and autoimmune disorders. Immune dysregulation in autoimmune diseases could contribute to the increased risk of atherosclerosis in these patients. Thus, immune modulation and anti-inflammatory treatments may help control the development of atherosclerosis in autoimmune disorders.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Atherosclerosis; autoimmune diseases; immune response; inflammation

Document Type: Research Article

Publication date: November 1, 2012

More about this publication?
  • Current Immunology Reviews publishes frontier reviews on all the latest advances in clinical immunology. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in clinical immunology.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more