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The Effects of Zataria Multiflora on Blood Glucose, Lipid Profile and Oxidative Stress Parameters in Adult Mice During Exposure to Bisphenol A

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Background: The present study evaluated the effects of Zataria multiflora (Z. multiflora) ethanolic extract on the hyperglycemia induced by bisphenol A (BPA).

Method: In the present research, mice were randomly selected into the following categories of 6 mice in each group: group one, control (C); group two, in which mice received 0.5 mg/kg of BPA, group three, in which mice received 2 mg/kg of BPA, group four, which was exposed to 0.5 mg/kg of BPA and received Z. multiflora and group five, which was exposed to 2 mg/kg of BPA and received Z. multiflora. The two doses of BPA were intraperitoneally administered to the positive control, however, the negative control injected only vehicle for 28 days. Z. multiflora (900 mg/kg) was administered orally to animals during injection of BPA exposure. After 28 days, the modulation of malondialdehyde (MDA), CAT (catalase), SOD (superoxide dismutase), glutathione (GSH), TAS (total antioxidant status), lipid profile, glucose, and total protein was evaluated in pancreas and serum.

Results: The analyzed data showed that Z. multiflora caused considerable decrease in glucose, total cholesterol (TC), triglyceride (TG) and MDA content with increase in GSH and total protein content in the serum of treated mice exposed to BPA (2 mg/kg/day), as compared to untreated mice exposed to BPA (2 mg/kg/day) (p<0.001). The MDA, TAS, and SOD levels were ameliorated in the pancreas of mice exposed to BPA (2mg/kg/day) after Z. multiflora administration (p<0.001).

Conclusion: These results suggest that Z. multiflora ameliorates hyperglycemia and hyperlipidemia in adult male mice exposed to BPA via inhibition of oxidative stress.
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Keywords: Adult mice; Zataria multiflora; bisphenol A; oxidative stress

Document Type: Research Article

Publication date: 01 April 2016

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  • Cardiovascular & Hematological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in cardiovascular and hematological disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal will contain a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in cardiovascular and hematological disorders. As the discovery, identification, characterization and validation of novel human drug targets for cardiovascular and hematological drug discovery continues to grow; this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.
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