Pharmacological Approaches of Alzheimer's Disease: An Update
Novel drugs that are currently in use or undergoing trial are briefly reviewed. To date, only a few acetylcholine esterase inhibitors have been licensed for AD, but more beneficial drugs are being actively sought by many different approaches. The development of additional drugs requires greater basic research on the pathogenesis of AD. Future therapeutic strategies for AD on the basis of recent findings concerning the pathogenesis of AD are also reviewed. Here, we review clinical features of the available cholinesterase inhibitors including their pharmacological properties and the emerging evidence for the use of memantine in AD. New therapeutic approaches including those more closely targeted to the pathogenesis of the disease will also be reviewed. Current treatments are briefly reviewed, followed by an introduction to emerging disease-modifying therapies.
Keywords: Alzheimer's disease; acetylcholine esterase inhibitors; cholinesterase inhibitors; current approaches; dementia; memantine; neurodegenerative disorder; pathogenesis of AD; senile plaques; treatment under investigation
Document Type: Research Article
Publication date: August 1, 2011
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