Skip to main content
padlock icon - secure page this page is secure

Apolipoprotein E: Possible Therapeutic Target for Atherosclerosis

Buy Article:

$68.00 + tax (Refund Policy)

Human apolipoprotein E (apoE) consists of a single polypeptide chain with 299 amino acids and is best known for its role in the transport of cholesterol and other lipids between peripheral tissues and the liver. However, more direct effects of apoE on the vascular wall may well contribute to arterial protection from atherosclerosis. This review will focus on: (a) the ability of apoE to direct cholesterol efflux mechanisms with the aid of apoA1 and the ATP binding cassette transporter 1 (ABC1) (b) the ability of apoE to prevent platelet aggregation by facilitating the production of endogenous nitric oxide (NO) (c) the ability of apoE to inhibit the proliferation of T-lymphocytes by internalization of the IL-2 receptor and (d) the ability of apoE to inhibit proliferation of endothelial cells by out competing growth factors for interaction with cell surface heparan sulfate proteoglycans (HSPG's). The characterization of apoE and its many functions has provided insight into the ultimate potential of this protein as a possible therapeutic agent for the treatment of atherosclerosis. This review will examine key scientific advances, which focus on possible therapeutic strategies that encompass the use of apoE in the amelioration of atherosclerosis.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: ATP binding cassette transporter 1 (ABC1); ApoE; Apolipoprotein; Atherosclerosis; Cell-based Gene Therapy; Cholesterol Efflux Mechanisms; Heparan sulfate proteoglycans; Intracellular nitric oxide synthase; Platelet Aggregation; macrophage colony-stimulating factor (M-CSF)

Document Type: Review Article

Publication date: December 1, 2001

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more