Isoniazid Induced Convulsions at Therapeutic Dose in an Alcoholic and Smoker Patient
We report a case of isoniazid induced convulsions in 35 years old male alcoholic and smoker patient receiving intensive phase therapy for pulmonary tuberculosis. A case was confirmed by accidental positive de-challenge and rechallenge as well as ruled out other conditions. Use of isoniazid
in alcoholic and smoker patient required a caution for prevention of neurological adverse reactions. Pyridoxine should always be prescribed to such patients for the prevention of such adverse reaction.
Keywords: Adverse drug reaction; alcohol; convulsions; isoniazid; pyridoxine deficiency; smoking
Document Type: Research Article
Publication date: 01 March 2015
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