Skip to main content
padlock icon - secure page this page is secure

Goto-kakizaki Rats: Its Suitability as Non-obese Diabetic Animal Model for Spontaneous Type 2 Diabetes Mellitus

Buy Article:

$68.00 + tax (Refund Policy)

β-cell dysfunction and apoptosis are recognized as a major cause of insufficient insulin secretion in response to high blood glucose and metabolic demand. As a consequence, type 2 diabetes mellitus (T2DM) is known to occur. Taking into account the etiology of T2DM, to conduct investigational studies directly on human diabetic patients seems to be unsuitable; thereby, various animal models have been established to investigate the pathogenesis of T2DM. Among these models, Goto-Kakizaki (GK) rats have been considered as one of the best non-obese type 2 diabetic animal model. GK rats exhibit valuable characteristic tools that are more or less common and functionally present in human diabetic patients. This animal model is considered appropriate to inspect various pathologic mechanisms of T2DM. Thereby, in our present article, we have comprehensively summarized the information relating the characteristics of abnormalities including a description of assorted mechanisms involved in pathogenesis of T2DM in GK rats. This might help to investigate various aspects of spontaneous T2DM.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Diabetes Mellitus; Diabetic Nephropathy; GK Rats; Glucose Tolerance; Hyperglycemia; Insulin Resistance; Islet Inflammation; None Obese Animal Model

Document Type: Research Article

Publication date: September 1, 2013

More about this publication?
  • Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy.

    The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more