@article {Niaz:2017:1389-2002:881,
title = "Health Benefits of Manuka Honey as an Essential Constituent for Tissue Regeneration",
journal = "Current Drug Metabolism",
parent_itemid = "infobike://ben/cdm",
publishercode ="ben",
year = "2017",
volume = "18",
number = "10",
publication date ="2017-10-01T00:00:00",
pages = "881-892",
itemtype = "ARTICLE",
issn = "1389-2002",
url = "https://www.ingentaconnect.com/content/ben/cdm/2017/00000018/00000010/art00005",
doi = "doi:10.2174/1389200218666170911152240",
keyword = "Honey, Leptospermum scoparium, tissue regeneration, antimicrobial, methyl-glyoxal, review, polyphenols, Manuka honey",
author = "Niaz, Kamal and Maqbool, Faheem and Bahadar, Haji and Abdollahi, Mohammad",
abstract = "Background: Honey is known for its therapeutic properties from ancient civilizations. Recently, the mechanism of action of Manuka honey in wound healing, epithelial regeneration, and ulcer treatments has been revealed. Objective: In the current review, the health perspectives of
honey, its chemical composition with special reference to flavonoids, polyphenol, and other bioactive trace compounds used in tissue regeneration have been discussed in detail. Methods: We undertook a structured search using wide spectrum sources like Google Scholar, PubMed, and Scopus.
Results: The included papers showed that Manuka honey can inhibit the process of carcinogenesis by controlling different molecular processes, and progression of cancer cells. Manuka honey has been found to have various biological activities, including antioxidant, antimicrobial and anti-proliferative
capacities. Scientists try to use Manuka honey in the area of tissue engineering to design a template for regeneration. Naturally derived antibacterial agents of Manuka honey are numerous mixtures of different compounds, which can influence antibacterial capacity. The non-peroxide bacteriostatic
properties of Manuka honey are associated with the presence of methylglyoxal (MGO). Conclusion: In addition to bacterial growth inhibition, glyoxal (GO) and MGO from Manuka honey can enhance wound healing and tissue regeneration by their immunomodulatory property. Further studies are
needed to provide detailed information about active components of Manuka honey and their potential efficacy in different diseases.",
}