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Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism and disposition. The journal serves as an international forum for the publication of timely reviews in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments. The journal covers the following areas:

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites and adducts.

Publisher: Bentham Science Publishers

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Volume 13, Number 7, 2012

Articles

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Catabolic Fate and Pharmacokinetic Characterization of Trastuzumab Emtansine (T-DM1): an Emphasis on Preclinical and Clinical Catabolism
pp. 901-910(10)
Authors: Shen, Ben-Quan; Bumbaca, Daniela; Saad, Ola; Yue, Qin; V. Pastuskovas, Cinthia; Cyrus Khojasteh, S.; Tibbitts, Jay; Kaur, Surinder; Wang, Bei; Chu, Yu-Waye; M. LoRusso, Patricia; Girish, Sandhya

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Drug Interaction Potential of Trastuzumab Emtansine (T-DM1) Combined with Pertuzumab in Patients With HER2-Positive Metastatic Breast Cancer
pp. 911-922(12)
Authors: Lu, Dan; A. Burris III, Howard; Wang, Bei; Claire Dees, E.; Cortes, Javier; Joshi, Amita; Gupta, Manish; Yi, Joo-Hee; Chu, Yu-Waye; Shih, Ted; Fang, Liang; Girish, Sandhya

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De-Risking Bio-therapeutics for Possible Drug Interactions Using Cryopreserved Human Hepatocytes
pp. 923-929(7)
Authors: Dallas, Shannon; Sensenhauser, Carlo; Batheja, Ameesha; Singer, Monica; Markowska, Maria; Zakszewski, Cindy; N.V.S. Mamidi, Rao; McMillia, Michael; Han, Chao; Zhou, Honghui; Silva, Jose

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Effects of Interleukin 1β (IL-1β) and IL-1β/Interleukin 6 (IL-6) Combinations on Drug Metabolizing Enzymes in Human Hepatocyte Culture
pp. 930-937(8)
Authors: J. Dickmann, Leslie; K. Patel, Sonal; C. Wienkers, Larry; Greg Slatter, J.

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Animal Models for Evaluation of Drug-Drug Interaction Potential of Biotherapeutics
pp. 947-950(4)
Authors: Kraynov, Eugenia; E. Dowty, Martin; Odette A. Fahmi, Odette; Fields, Owen

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The SmartAmp Method: Rapid Detection of SNPs in Thiopurine S-Methyltransferase and ABC Transporters ABCC4 and ABCG2
pp. 968-977(10)
Authors: Aw, Wanping; Lezhava, Alexander; Andoh, Akira; Tanaka, Hiroshi; Hayashizaki, Yoshihide; Ishikawa, Toshihisa

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SNP Web Resources and Their Potential Applications in Personalized Medicine
pp. 978-990(13)
Authors: Wang, Jingbo; S.Y. Pang, Grace; S. Chong, Samuel; G.L. Lee, Caroline

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The Importance of Integrating SNP and Cheminformatics Resources to Pharmacogenomics
pp. 991-999(9)
Authors: Chang, Hsueh-Wei; Chuang, Li-Yeh; Tsai, Ming-Tz; Yang, Cheng-Hong

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Personalized Medicine: Potential, Barriers and Contemporary Issues
pp. 1000-1006(7)
Authors: J. Sorich, Michael; A. McKinnon, Ross

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Detection of EGFR Somatic Mutations in Non-Small Cell Lung Cancer (NSCLC) Using a Novel Mutant-Enriched Liquidchip (MEL) Technology
pp. 1007-1011(5)
Authors: Zhang, Li; Yang, Huiyi; Zhao, Yanwei; Liu, Wenchao; Wu, Shiyang; He, Jiaying; Luo, Xiaodi; Zhu, Zeyao; Xu, Jiasen; Zhou, Qinghua; Ren-Heidenreich, Lifen

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Prediction and Functional Analysis of Single Nucleotide Polymorphisms
pp. 1012-1023(12)
Authors: Li, Li; Chen, Qi; Wei, Dong-Qing

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Negatively Cooperative Binding Properties of Human Cytochrome P450 2E1 with Monocyclic Substrates
pp. 1024-1031(8)
Authors: Ping, Jie; Wang, Ya-Jun; Wang, Jing-Fang; Li, Xuan; Li, Yi-Xue; Hao, Pei

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