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Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism and disposition. The journal serves as an international forum for the publication of timely reviews in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments. The journal covers the following areas:

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites and adducts.

Publisher: Bentham Science Publishers

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Volume 13, Number 6, 2012

Articles

Free Content Editorial (Hot Topic: Pregnancy and Pediatrics)
pp. 693-693(1)
Author: N. de Wildt, Saskia

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Physiologically-based Pharmacokinetic (PBPK) Models for Assessing the Kinetics of Xenobiotics during Pregnancy: Achievements and Shortcomings
pp. 695-720(26)
Authors: Lu, G.; Abduljalil, K.; Jamei, M.; N. Johnson, T.; Soltani, H.; Rostami-Hodjegan, A.

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Pharmacogenetics of Opioids for the Treatment of Acute Maternal Pain During Pregnancy and Lactation
pp. 721-727(7)
Authors: Madadi, Parvaz; Avard, Denise; Koren, Gideon

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Ontogeny of Hepatic Glucuronidation; Methods and Results
pp. 728-743(16)
Authors: H.J. Krekels, Elke; Danhof, Meindert; Tibboel, Dick; A.J. Knibbe, Catherijne

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Pharmacokinetic Considerations of Perinatal Antiretroviral Therapy
pp. 744-759(16)
Authors: Y. Rakhmanina, Natella; Dirajlal-Fargo, Sahera; V. Capparelli, Edmund; Mirochnik, Mark

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Growing up with Midazolam in the Neonatal and Pediatric Intensive Care
pp. 760-766(7)
Authors: L. Swart, Eleonora; R. Slort, Pauline; B. Plotz, Frans

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Pharmacotherapy in Neonatal and Pediatric Extracorporeal Membrane Oxygenation (ECMO)
pp. 767-777(11)
Authors: D. Wildschut, E.; J. Ahsman, M.; J. Houmes, R.; Pokorna, P.; N. de Wildt, S.; A.A. Mathot, R.; Tibboel, D.

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Sex Differences in the Clearance of CYP3A4 Substrates: Exploring Possible Reasons for the Substrate Dependency and Lack of Consensus
pp. 778-786(9)
Authors: Chetty, Manoranjenni; Mattison, Donald; Rostami-Hodjegan, Amin

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Intracellular Disposition of Methotrexate in Acute Lymphoblastic Leukemia in Children
pp. 822-834(13)
Authors: Adam de Beaumais, Tiphaine; Jacqz-Aigrain, Evelyne

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Active Metabolites Resulting from Decarboxylation, Reduction and Ester Hydrolysis of Parent Drugs
pp. 835-862(28)
Authors: Hartyanszky, I.; Kalasz, H.; Adeghate, E.; Gulyas, Zs.; Y. Hasan, M.; Tekes, K.; Adem, A.; Sotonyi, P.

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