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Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism and disposition. The journal serves as an international forum for the publication of timely reviews in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments. The journal covers the following areas:

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites and adducts.

Publisher: Bentham Science Publishers

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Volume 13, Number 2, 2012

Articles

Is There a Relationship Between the Substrate Preferences and Structural Flexibility of Cytochromes P450?
pp. 130-142(13)
Authors: Otyepka, Michal; Berka, Karel; Anzenbacher, Pavel

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Multiple, Ligand-dependent Routes from the Active Site of Cytochrome P450 2C9
pp. 143-154(12)
Authors: Cojocaru, Vlad; J. Winn, Peter; C. Wade, Rebecca

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The Role of Protein Plasticity in Computational Rationalization Studies on Regioselectivity in Testosterone Hydroxylation by Cytochrome P450 BM3 Mutants
pp. 155-166(12)
Authors: B.A. de Beer, Stephanie; A.H. van Bergen, Laura; Keijzer, Karlijn; Rea, Vanina; Venkataraman, Harini; Fonseca Guerra, Celia; Matthias Bickelhaupt, F.; P.E. Vermeulen, Nico; N.M. Commandeur, Jan; P. Geerke, Daan

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Plasticity of CYP2B Enzymes: Structural and Solution Biophysical Methods
pp. 167-176(10)
Authors: Ross Wilderman, P.; R. Halpert, James

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Dynamics and Hydration of the Active Sites of Mammalian Cytochromes P450 Probed by Molecular Dynamics Simulations
pp. 177-189(13)
Authors: Hendrychova, Tereza; Berka, Karel; Navratilova, Veronika; Anzenbacher, Pavel; Otyepka, Michal

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Malleability and Versatility of Cytochrome P450 Active Sites Studied by Molecular Simulations
pp. 190-196(7)
Authors: Oostenbrink, Chris; de Ruiter, Anita; Hritz, Jozef; Vermeulen, Nico

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Liver-Based In Vitro Technologies for Drug Biotransformation Studies - A Review
pp. 215-224(10)
Authors: Fasinu, Pius; J. Bouic, Patrick; Rosenkranz, Bernd

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An insight into the Interaction between Clopidogrel and Proton Pump Inhibitors
pp. 225-235(11)
Authors: S. Shah, Bhavik; A. Parmar, Sanjay; Mahajan, Shailaja; A. Mehta, Anita

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