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Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism and disposition. The journal serves as an international forum for the publication of timely reviews in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments. The journal covers the following areas:

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites and adducts.

Publisher: Bentham Science Publishers

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Volume 12, Number 8, 2011

Articles

Modulation and Absorption of Xenobiotics: The Synergistic Role of CYP450 and P-gp Activities in Cancer and Neurodegenerative Disorders
pp. 702-712(11)
Authors: Inglese, Carmela; Grazia Perrone, Maria; Berardi, Francesco; Perrone, Roberto; Antonio Colabufo, Nicola

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The Coordinated Role of CYP450 Enzymes and P-gp in Determining Cancer Resistance to Chemotherapy
pp. 713-721(9)
Authors: Azzariti, Amalia; Porcelli, Letizia; Elisa Quatrale, Anna; Silvestris, Nicola; Paradiso, Angelo

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P-glycoprotein Inhibition: The Past, the Present and the Future
pp. 722-731(10)
Authors: A.J. Darby, Richard; Callaghan, Richard; M. McMahon, Roisin

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Interplay of Drug Metabolizing CYP450 Enzymes and ABC Transporters in the Blood-Brain Barrier
pp. 732-741(10)
Authors: Decleves, Xavier; Jacob, Aude; Yousif, Salah; Shawahna, Ramzi; Potin, Sophie; Scherrmann, Jean-Michel

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Blood-Brain Barrier P450 Enzymes and Multidrug Transporters in Drug Resistance: A Synergistic Role in Neurological Diseases
pp. 742-749(8)
Authors: Ghosh, Chaitali; Puvenna, Vikram; Gonzalez-Martinez, Jorge; Janigro, Damir; Marchi, Nicola

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In Silico, In Vitro and In Situ Models to Assess Interplay Between CYP3A and P-gp
pp. 750-773(24)
Authors: R. Mudra, Daniel; E. Desino, Kelly; V. Desai, Prashant

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PET and SPECT Radiotracers to Assess Function and Expression of ABC Transporters In Vivo
pp. 774-792(19)
Authors: Mairinger, Severin; Erker, Thomas; Muller, Markus; Langer, Oliver

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