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Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism and disposition. The journal serves as an international forum for the publication of timely reviews in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments. The journal covers the following areas:

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites and adducts.

Publisher: Bentham Science Publishers

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Volume 9, Number 9, 2008

Articles

High Throughput ADME Screening: Practical Considerations, Impact on the Portfolio and Enabler of In Silico ADME Models
pp. 847-853(7)
Authors: Hop, Cornelis E.C.A.; Cole, Mark J.; Davidson, Ralph E.; Duignan, David B.; Federico, James; Janiszewski, John S.; Jenkins, Kelly; Krueger, Suzanne; Lebowitz, Rebecca; Liston, Theodore E.; Mitchell, Walter; Snyder, Mark; Steyn, Stefan J.; Soglia, John R.; Taylor, Christine; Troutman, Matt D.; Umland, John; West, Michael; Whalen, Kevin M.; Zelesky, Veronica; Zhao, Sabrina X.

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Plasma / Serum Protein Binding Determinations
pp. 854-859(6)
Authors: Banker, Michael J.; Clark, Tracey H.

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Solution Stability - Plasma, Gastrointestinal, Bioassay
pp. 860-868(9)
Authors: Di, Li; Kerns, Edward H.

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In Vitro Solubility Assays in Drug Discovery
pp. 879-885(7)
Authors: Kerns, Edward H.; Di, Li; Carter, Guy T.

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Artificial Membrane Assays to Assess Permeability
pp. 886-892(7)
Author: Faller, Bernard

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Permeability for Intestinal Absorption: Caco-2 Assay and Related Issues
pp. 893-900(8)
Authors: Press, Barry; Di Grandi, Deanna

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Assays to Predict Drug Permeation Across the Blood-Brain Barrier, and Distribution to Brain
pp. 901-910(10)
Authors: Abbott, N. J.; Dolman, D. E.M.; Patabendige, A. K.

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In Vitro Cytochrome P450 Inhibition and Induction
pp. 928-939(12)
Authors: Walsky, Robert L.; Boldt, Sherri E.

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Methods for Predicting In Vivo Pharmacokinetics Using Data from In Vitro Assays
pp. 940-951(12)
Authors: Houston, J. B.; Galetin, Aleksandra

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In Vitro Screening Techniques for Reactive Metabolites for Minimizing Bioactivation Potential in Drug Discovery
pp. 952-964(13)
Authors: Prakash, Chandra; Sharma, Raman; Gleave, Michelle; Nedderman, Angus

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hERG (KCNH2 or Kv11.1) K+ Channels: Screening for Cardiac Arrhythmia Risk
pp. 965-970(6)
Authors: Bowlby, Mark R.; Peri, Ravi; Zhang, Howard; Dunlop, John

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The Role of Genetic Toxicology in Drug Discovery and Optimization
pp. 978-985(8)
Authors: Custer, L. L.; Sweder, K. S.

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Perspectives on Bioanalytical Mass Spectrometry and Automation in Drug Discovery
pp. 986-994(9)
Authors: Janiszewski, John S.; Liston, Theodore E.; Cole, Mark J.

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