Release Kinetics of Nicotine Loaded onto Mesoporous Silicate Materials for Use in Nicotine Replacement Therapy
In this work, the loading of nicotine onto mesoporous silicate materials and its release into a phosphate buffer solution at 37°C were investigated. The mesoporous silicate materials designated as MCM-41 were prepared with different pore sizes via using alkyltrimethylammonium bromide surfactants with different alkyl chain lengths of carbon atoms 12, 14, and 16. The mesoporous silicate systems were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), N2-adsorption– desorption isotherms, and FT-IR spectroscopy. Loading of nicotine was confirmed by FTIR and thermal gravimetric analysis and was determined by high-performance liquid chromatography (HPLC). A slight increase in loading capacity with increasing pore size was observed, with a loading capacity of about 17% for MCM-41(16). The release of nicotine was monitored by HPLC and was almost complete for MCM-41(14) and MCM-41(16) in 8 h.
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