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Open Access Simvastatin Loaded Nano Hydroxyapatite in Bone Regeneration: A Study in the Rabbit Femoral Condyle

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Background: Enhancement of the bone regenerative capacity of the bone substitutes could be achieved by incorporating bioactive agents such as proteins, and different drugs. Simvastatin, an inhibitor of cholesterol synthesis, stimulates bone formation by enhancing the expression of Bone Morphogenetic Protein-2 (BMP-2) in osteoblasts.

Objective: The objective of the study is to evaluate bone regeneration following simvastatin loaded nano-hydroxyapatite scaffold in the bone defect created on the femoral condyle of rabbits.

Methods: Twelve adult, New Zealand white rabbits were used in the study. Twenty-four defects of size 5x8 mm were created on the lateral aspect of the femoral condyle. The defects were filled with either Nano-Hydroxyapatite (nHA) particles alone or nHA with Simvastatin (SIM). The condyles were retrieved after 8 weeks and analyzed using micro CT and histology.

Results: The Bone Mineral Density (BMD) was significantly higher for the defects filled with SIM loaded nHA compared to the nHA site. Micro CT showed a significantly higher bone volume in the defects filled with Simvastatin loaded site compared to the control site. Quantitative analysis of the histologic sections also showed significantly higher bone volume in the defects filled with SIM loaded nHA (57.2±4.8) compared to nHA alone (50.1±5.5).

Conclusion: Based on the results, it can be concluded that local delivery of simvastatin enhanced the bone regeneration in rabbit femoral condyle. Simvastatin could be used as an activator to enhance bone regeneration in bone defects along with hydroxyapatite ceramics.
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Keywords: Bone regeneration; drug delivery system; nano-hydroxyapatite; osteoconductivity; simvastatin; tissue engineering

Document Type: Research Article

Publication date: July 1, 2019

This article was made available online on June 17, 2019 as a Fast Track article with title: "Simvastatin Loaded Nano Hydroxyapatite in Bone Regeneration: A Study in the Rabbit Femoral Condyle".

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  • The aim of Current Drug Delivery is to publish peer-reviewed articles, short communications, short and in-depth reviews in the rapidly developing field of drug delivery. Modern drug research aims to build in delivery properties of a drug at the design phase, however in many cases this ideal cannot be met and the development of delivery systems becomes as important as the development as the drugs themselves.

    The journal aims to cover the latest outstanding developments in drug and vaccine delivery employing physical, physico-chemical and chemical methods. The drugs include a wide range of bioactive compounds from simple pharmaceuticals to peptides, proteins, nucleotides, nucleosides and sugars. The journal will also report progress in the fields of transport routes and mechanisms including efflux proteins and multi-drug resistance.

    The journal is essential for all pharmaceutical scientists involved in drug design, development and delivery.
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