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Studying the Effects of Classic Hallucinogens in the Treatment of Alcoholism: Rationale, Methodology, and Current Research with Psilocybin

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Recent developments in the study of classic hallucinogens, combined with a re-appraisal of the older literature, have led to a renewal of interest in possible therapeutic applications for these drugs, notably their application in the treatment of addictions. This article will first provide a brief review of the research literature providing direct and indirect support for the possible therapeutic effects of classic hallucinogens such as psilocybin and lysergic acid diethylamide (LSD) in the treatment of addictions. Having provided a rationale for clinical investigation in this area, we discuss design issues in clinical trials using classic hallucinogens, some of which are unique to this class of drug. We then discuss the current status of this field of research and design considerations in future randomized trials.
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Keywords: Addiction; alcohol dependence; alcoholism; clinical trials; drug abuse; hallucinogens; psilocybin; psychedelic drugs

Document Type: Research Article

Publication date: March 1, 2013

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  • Current Drug Abuse Reviews aims to publish the highest quality reviews, meta-analyses and drug clinical trial studies on all latest advances on alcohol and drug abuse and addiction.

    Book reviews are also published. The Journal will further comprise an agenda listing relevant meetings and conferences that will take place in near future, and advertisement.

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