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Endocrinology and Immunology of Obesity, Obesity Vaccines

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The amount of body fat is precisely regulated in the overall process of energy homeostasis. Multiple organ systems participate in the regulatory process. Key regulatory signals reach the brain from the blood and control food intake and energy expenditure. The hypothalamus region integrates neurohormonal signaling from gut and adipose tissue. Morbid obesity is also associated with low grade systemic inflammation and immune activation. It can be at least in part regarded as an inflammatory disease. The anti-ghrelin vaccine decreases food intake, decreases hypothalamic orexigenic signals and increases energy expenditure and therefore might become an alternative treatment tool.
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Keywords: Adiposity signals; anti-ghrelin vaccine; hypothalamus; inflammatory state; intestinal peptides; neuropeptides; obesity

Document Type: Research Article

Publication date: August 1, 2013

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  • Current Clinical Pharmacology publishes frontier reviews on all the latest advances in clinical pharmacology. The journal's aim is to publish the highest quality review articles in the field. Topics covered include: pharmacokinetics; therapeutic trials; adverse drug reactions; drug interactions; drug metabolism; pharmacoepidemiology; and drug development. The journal is essential reading for all researchers in clinical pharmacology.
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