Skip to main content
padlock icon - secure page this page is secure

Evolutionary Significance of Iodine

Buy Article:

Your trusted access to this article has expired.

$63.00 + tax (Refund Policy)

The significance of inorganic and organic forms of iodine in the evolution of plants and animals is reviewed. Iodine is one of the most electron-rich atoms in the diet of marine and terrestrial organisms, and it enters cells via iodide transporters. Iodide, which acts as a primitive electron donor through peroxidase enzymes, has an ancestral antioxidant function in all iodide-concentrating cells from primitive marine algae to more recent terrestrial vertebrates. Similarly, thyroxine and iodothyronines show antioxidant activities through deiodinase enzymes. About 500-600 million years ago, in parallel with the evolution of the primitive brain in marine animals, thyroid cells originated from the primitive gut in vertebrates, migrated, and specialized in the uptake and storage of iodo-compounds in a novel follicular “thyroidal” structure, an adaptation that enabled the transition from the iodine-rich ocean to the iodine-deficient terrestrial environment.

No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Antioxidants; Hypoiodite ion; Hypoiodous acid; Thyroid hormones; Thyroid-hormone receptors; Triiodothyronine; evolution; iodide; iodine; thyroxine

Document Type: Research Article

Publication date: 01 September 2011

More about this publication?
  • Current Chemical Biology aims to publish full-length and mini reviews on exciting new developments at the chemistry-biology interface, covering topics relating to Chemical Synthesis, Science at Chemistry-Biology Interface and Chemical Mechanisms of Biological Systems.

    Current Chemical Biology covers the following areas: Chemical Synthesis (Syntheses of biologically important macromolecules including proteins, polypeptides, oligonucleotides, oligosaccharides etc.; Asymmetric synthesis; Combinatorial synthesis; Diversity-oriented synthesis; Template-directed synthesis; Biomimetic synthesis; Solid phase biomolecular synthesis; Synthesis of small biomolecules: amino acids, peptides, lipids, carbohydrates and nucleosides; and Natural product synthesis).

    Science at Chemistry-Biology Interface (Chemical informatics; Macromolecular catalysts and receptors; Enzymatic synthesis; Biosynthetic engineering; Combinatorial biosynthesis; Plant cell based chemistry; Bacterial and viral cell based chemistry; Chemistry of cellular processes in plants/animals; Receptor chemistry; Cell signaling chemistry; Drug design through understanding of disease processes; Synthetic biology; New high throughput screening techniques; Small molecular array fabrication; Chemical genomics; Chemical and biological approaches to carbohydrates proteins and nucleic acids design; Chemical and biological regulation of biosynthetic pathways; and Unnatural biomolecular analogs).
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more