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The Role of STAT 3 in Tissue Fibrosis

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Signal transducer and activator of transcription 3 (STAT3) is a transcriptional factor and has been implicated in cell proliferation, survival and differentiation. Recent studies demonstrate that STAT3 activity is persistently elevated in patients with some chronic disorders, and required for the development and progression of fibrosis in a variety of tissues including kidney, bone marrow and skin. On the other hand, STAT3 is implicated in tissue protection against fibrosis in the heart following acute injury. Moreover, STAT3 can either promote or protect against tissue fibrosis in chronic liver disease models, depending on etiologies. The underlying mechanisms by which STAT3 mediates those cellular events are not fully understood, but the profibrotic action of STAT3 is mostly associated with activation and proliferation of fibroblasts, deposition of excessive extracellular matrix proteins, and overproduction of some cytokines. In this review article, we discuss the role of STAT3 in tissue fibrosis and the effect of the STAT3 pathway inhibition on the proliferation and activation of fibroblasts in vitro and fibrogenesis in various animal models.

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Keywords: Astrocytes; C-terminal transactivation; DNA binding; Idiopathic pulmonary fibrosis (IPF); IgA; Immunofluorescence; Keloid; Receptors; Renal Interstitial Fibrosis; STAT3; Spinal Cord Injury; aging; allergic responses; autoimmune; bleomycin injury; bone marrow; carbon tetrachlorideinduced; central nervous system; chronic autoimmune diseases or rachitis; cirrhosis; coiled-coil; collagen deposition; cytokines; cytokines/growth factors; cytoplasmic transcription; diabetic; epithelial cells; extracellular matrix; fibroblasts; fibrogenic actions; fibroproliferative diseases; glial cells; glomerular sclerosis; glomerulonephritis; growth factor, (TGF); hardening; hematopoetic factors; hemodynamic; hepatic stellate cells; hyperactivation; hyperfiltration; hypertension; inflammatory cells; interstitial edema; kidney; leukocytes; metabolic disorders; migration; motor recovery; myeloid metaplasia; myocardial infarction; nephron; neutrophils; obstructive nephropathy; organ failure; oxidative stress; parasitic diseases; pathogenesis of tissue; phosphorylation; platelet derived growth factor (PDGF); proliferation; protein-protein interactions; skin lesions; smooth actin; syndrome; tissue fibrosis; traumatic injuries; tyrosine kinase; unilateral ureteral obstruction (UUO); urinary albumin excretion; visceral epithelium

Document Type: Research Article

Publication date: January 1, 2011

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  • Current Chemical Biology aims to publish full-length and mini reviews on exciting new developments at the chemistry-biology interface, covering topics relating to Chemical Synthesis, Science at Chemistry-Biology Interface and Chemical Mechanisms of Biological Systems.

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    Science at Chemistry-Biology Interface (Chemical informatics; Macromolecular catalysts and receptors; Enzymatic synthesis; Biosynthetic engineering; Combinatorial biosynthesis; Plant cell based chemistry; Bacterial and viral cell based chemistry; Chemistry of cellular processes in plants/animals; Receptor chemistry; Cell signaling chemistry; Drug design through understanding of disease processes; Synthetic biology; New high throughput screening techniques; Small molecular array fabrication; Chemical genomics; Chemical and biological approaches to carbohydrates proteins and nucleic acids design; Chemical and biological regulation of biosynthetic pathways; and Unnatural biomolecular analogs).
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