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Relationship Between Metal Transcription Factor-1 and Zinc in Resistance to Metals Producing Free Radicals

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Trace elements as Cu (copper), Fe (iron), and Zn (zinc) can be toxic when their distribution is not carefully regulated, and also their inappropriate binding may compromise cellular function and homeostatic mechanisms. Metal transcription factor-1 (MTF-1), a multiple Zn finger protein, activates metal response element-driven (reporter) gene expression, in a similar way as it happens in metallothionein-1 and -2 (MT-1 and MT-2), zinc transporter-1 (ZnT-1), superoxide dismutase (SOD) and γ-glutamylcysteine synthetase (γ-GCS), a rate-determining enzyme of glutathione synthesis. Virtually, MTF-1 directly coordinates the regulation of genes involved in Zn homeostasis and the protection against metal toxicity. This transcription factor is able to sense changes in metal concentrations and coordinate the expression of genes involved in acquisition, distribution, sequestration, and use of metals. This review is focused on the role of MTF-1 in regulating trace metal metabolism and gene expression of some proteins such as, for example, MT-1, MT-2 and ZnT-1. The aim of the study has been to investigate the role of MTF-1 on the Cu, Fe and Zn uptake and accumulation, and the gene expression of some proteins involved in homeostasis of trace metals in MTF-1 mutant cells as compared to their wild-type cells also were considered.





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Keywords: Trace elements; divalent metal transporter 1; glutathione; metal transcription factor-1; metallothionein; zinc transporter

Document Type: Research Article

Publication date: September 1, 2008

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  • Current Chemical Biology aims to publish full-length and mini reviews on exciting new developments at the chemistry-biology interface, covering topics relating to Chemical Synthesis, Science at Chemistry-Biology Interface and Chemical Mechanisms of Biological Systems.

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    Science at Chemistry-Biology Interface (Chemical informatics; Macromolecular catalysts and receptors; Enzymatic synthesis; Biosynthetic engineering; Combinatorial biosynthesis; Plant cell based chemistry; Bacterial and viral cell based chemistry; Chemistry of cellular processes in plants/animals; Receptor chemistry; Cell signaling chemistry; Drug design through understanding of disease processes; Synthetic biology; New high throughput screening techniques; Small molecular array fabrication; Chemical genomics; Chemical and biological approaches to carbohydrates proteins and nucleic acids design; Chemical and biological regulation of biosynthetic pathways; and Unnatural biomolecular analogs).
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