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Current Issues in Tumor Immunology

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The goal of tumor immunology is to understand the interactions between tumor cells and immune system, and ultimately to devise immune basedapproaches to fight cancer. We discuss here recent advances in tumor immunology and in the interaction between immunology and informatics that provide new perspectives for the development of cancer therapy. Cancer immunoprevention is a novel approach to cancer prevention through the use of vaccines and other immunological strategies to be applied before tumor onset. The efficacy of cancer immunoprevention has been demonstrated in several experimental systems, however, as frequently happens in novel approaches, cancer immunoprevention studies incorporate a large number of variables. We show here how a specifically designed lattice gas model can provide significant insight for the analysis of immune variables and the design of new biological experiments. A second approach that provides new perspectives in tumor immunology as the result of interactions between immunology and informatics is the use of DNA microarrays to investigate and monitor tumor-host relationships and modifications induced by immunopreventive and immunotherapeutic interventions.

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Keywords: Cancer immunoprevention; DNA microarrays; HER-2/neu; computational models; systems biology

Document Type: Research Article

Publication date: September 1, 2010

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  • Current Bioinformatics aims to publish all the latest and outstanding developments in bioinformatics. Each issue contains a series of timely, in-depth reviews written by leaders in the field, covering a wide range of the integration of biology with computer and information science.

    The journal focuses on reviews on advances in computational molecular/structural biology, encompassing areas such as computing in biomedicine and genomics, computational proteomics and systems biology, and metabolic pathway engineering. Developments in these fields have direct implications on key issues related to health care, medicine, genetic disorders, development of agricultural products, renewable energy, environmental protection, etc.

    Current Bioinformatics is an essential journal for all academic and industrial researchers who want expert knowledge on all major advances in bioinformatics.
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