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An Integrated Rule-Set for Protein Localization in Plasmodium falciparum

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Proteins localize to many intracellular and extracellular organelles in the malarial parasite Plasmodium falciparum. Although organellar localization in the parasite has been studied in detail, there is a need for a comprehensive ruleset that captures the different paths and mechanisms used by proteins for localization. This review is an attempt to build such a rule-set through a combination of rules gleaned from literature reports. A prototype localization prediction tool has also been implemented by incorporating certain sequence/composition rules from the rule-set.

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Keywords: Plasmodium falciparum; Targetpf; integrated rule-set; protein localization

Document Type: Research Article

Publication date: May 1, 2008

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  • Current Bioinformatics aims to publish all the latest and outstanding developments in bioinformatics. Each issue contains a series of timely, in-depth reviews written by leaders in the field, covering a wide range of the integration of biology with computer and information science.

    The journal focuses on reviews on advances in computational molecular/structural biology, encompassing areas such as computing in biomedicine and genomics, computational proteomics and systems biology, and metabolic pathway engineering. Developments in these fields have direct implications on key issues related to health care, medicine, genetic disorders, development of agricultural products, renewable energy, environmental protection, etc.

    Current Bioinformatics is an essential journal for all academic and industrial researchers who want expert knowledge on all major advances in bioinformatics.
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