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Earthworms as a Source of Bioactive Molecules

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Searching for bioactive molecules from natural source represents an attractive strategy. Natural bioactive molecules form the backbone of modern therapeutics. For that reason the glycolipoprotein extract (G-90) from tissue homogenate of earthworm Eisenia foetida represents a valuable source of bioactive molecules. The molecules in this preparation exhibit many biological characteristics, useful in different biological processes. This extract showed interaction with biological materials from evolutionary more developed species, such as serums, erythrocytes, normal and transformed cells in culture from different origin. The numerous biological activities in vitro and in vivo, such as mitogenicity, anticoagulation, fibrinolysis, bacteriostasis, antioxidation, were detected in G-90. In therapeutic concentrations G-90 was not toxic, allergenic, mutagen or carcinogen. G-90 protected cells in culture from oxidative damage, caused by hydrogen peroxide. It is capable to stimulate the cellular immune system. As fibrinolytic and anticoagulative agent it can participate in active maintenance of homeostasis. G-90 has the ability to stimulate the synthesis of growth factors and helps in tissue regeneration. It stimulates proliferation of fibroblasts and epithelial cells, as well as their differentiation. Accordingly, G- 90 is a valuable mixture of bioactive molecules from natural source, which could be very useful in human and veterinary medicine.

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Keywords: Eisenia foetida; G-90; Review; bioactive molecules; earthworm

Document Type: Research Article

Publication date: June 1, 2009

More about this publication?
  • The journal aims to provide updates to researchers about new bioactive compounds with proven activities in various biological screenings and pharmacological models. The journal will contain information about the structures, biological activities and sources of chemical entities discovered or designed by researchers and published in leading journals. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia.

    The journal should prove to be essential reading for pharmacologists, pharmaceutical chemists and medicinal chemists who wish to be kept informed and up-to-date with the latest and most important developments about new bioactive compounds of natural or synthetic origin, including recent patents.
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