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Natural Antiulcerogenic Agents: An Overview

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Extensive use of certain drugs, changes in lifestyles and food habits, as well as stress factors in modern human lives have led to an exponential increase in the incidence of gastric ulceration. The ideal anti-ulcer drug with less side effects and recurrence, and affordability has so far remains elusive, providing avenues for innovation, especially with phytochemicals. This review furnishes extensive information on the earlier works carried out in this area and rationalizes the mode of action of them, citing limitations of the previous studies. The primary aim was to cover different classes of potent natural compounds that have impressive gastro-protective property against various ulcerogens (except Helicobacter pylori infection), and are available in large quantities from the natural sorces. A few examples of synthetic congeners have also been included to highlight the type of innovation that may be required for developing new drugs.

Keywords: Genesis And Therapy; Natural Antiulcerogenic Agents; anti-inflammatory drugs; cytokines; gastric ulceration; natural sorces

Document Type: Research Article

Publication date: December 1, 2008

More about this publication?
  • The journal aims to provide updates to researchers about new bioactive compounds with proven activities in various biological screenings and pharmacological models. The journal will contain information about the structures, biological activities and sources of chemical entities discovered or designed by researchers and published in leading journals. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia.

    The journal should prove to be essential reading for pharmacologists, pharmaceutical chemists and medicinal chemists who wish to be kept informed and up-to-date with the latest and most important developments about new bioactive compounds of natural or synthetic origin, including recent patents.
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