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Prognosis of Possible Reassortments in Recent H5N2 Epidemic Influenza in USA: Implications for Computer-Assisted Surveillance As Well As Drug/Vaccine Design

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The recent H5N2 flu epidemic in US Midwest has led to deaths of millions of turkeys and farm bred poultry. While no human infections are reported to date, the rapid mutations in flu viruses can lead to more pathogenic subtypes. We have investigated such possibilities and have shown that H5N4, H5N9 and H5N6 are the most likely candidates for next round of viral reassortments, amongst which H5N9, if reassorted from Asiatic strains, could be highly pathogenic. We discuss here possibilities of anticipatory rational vaccine design based on work done earlier.
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Keywords: Graphical representation of RNA sequences; H5N2 influenza; HA-NA interdependence; North American H5N2 epidemic; prognosis of flu reasortments; reassortments

Document Type: Research Article

Publication date: June 1, 2015

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  • Current Computer-Aided Drug Design aims to publish all the latest developments in drug design based on computational techniques. The field of computer-aided drug design has had extensive impact in the area of drug design. Current Computer-Aided Drug Design is an essential journal for all medicinal chemists who wish to be kept informed and up-to-date with all the latest and important developments in computer-aided methodologies and their applications in drug discovery. Each issue contains a series of timely, in-depth reviews written by leaders in the field, covering a range of computational techniques for drug design, screening, ADME studies, etc., providing excellent rationales for drug development.
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