Skip to main content
padlock icon - secure page this page is secure

Mini-Review: Recent Developments in Hydroxynitrile Lyases for Industrial Biotechnology

Buy Article:

$68.00 + tax (Refund Policy)

Hydroxynitrile lyases (HNLs) catalyze the cleavage as well as the formation of cyanohydrins. The latter reaction is valuable for the stereoselective C-C bond formation by condensation of HCN with carbonyl compounds. The resulting cyanohydrins serve as versatile building blocks for a broad range of chemical and enzymatic follow-up reactions. A significant number of (R)- and (S)-selective HNLs are known today and the number is still increasing. HNLs not only exhibit varying substrate scope but also differ in sequence and structure. Tailor-made enzymes for large-scale manufacturing of cyanohydrins with improved yield and enantiomeric excess are very interesting targets, which is reflected in a solid number of patents. This review will complement and extend our recent review with a strong focus on applications of HNLs for the synthesis of highly functionalized, chiral compounds with newest literature, recent and current patent literature.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Asymmetric synthesis; C-C coupling; HNL; biocatalysis; biotransformation; cascade reactions; chiral building blocks; cyanogenesis; cyanohydrin; enantioselectivity; enzyme engineering; hydrocyanic acid; hydroxynitrile lyase; industrial process; mandelonitrile lyase; oxynitrilase; plant enzymes; stereoselective

Document Type: Research Article

Publication date: December 1, 2013

More about this publication?
  • Recent Patents on Biotechnology publishes review articles by experts on recent patents on biotechnology. A selection of important and recent patents on biotechnology is also included in the journal. The journal is essential reading for all researchers involved in all fields of biotechnology.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more