@article {Swain:2013:1872-2083:28,
title = "Stabilization and Delivery Approaches for Protein and Peptide Pharmaceuticals: An Extensive Review of Patents",
journal = "Recent Patents on Biotechnology",
parent_itemid = "infobike://ben/biot",
publishercode ="ben",
year = "2013",
volume = "7",
number = "1",
publication date ="2013-04-01T00:00:00",
pages = "28-46",
itemtype = "ARTICLE",
issn = "1872-2083",
url = "https://www.ingentaconnect.com/content/ben/biot/2013/00000007/00000001/art00004",
keyword = "Degradation pathways, delivery approaches, stabilization, patents",
author = "Swain, Suryakanta and Mondal, Debanik and Beg, Sarwar and Niranjan Patra, Chinam and Chandra Dinda, Subas and Sruti, Jammula and Eswara Bhanoji Rao, Muddana",
abstract = "Proteins and peptides are the building blocks of human body and act as the arsenal to combat against the invading pathogenic organisms for treatment and management of diseases. Majority of such biomacromolecules are synthesized by the human body itself. However, entry of disease causing
pathogens causes misleading in the synthesis of desired proteins for antibody formation. In such alarming situations, the delivery of requisite protein and peptide from external source helps in augmenting the body's immunity. The major drawbacks underlying poor biopharmaceutical performance
of high molecular weight protein and peptide drugs are due to poor oral absorption, formulation stability, degradation in the gastric milieu, susceptible to presystemic metabolism. Numerous literature recounts the application of myriad drug delivery strategies for the effective delivery of
protein and peptides viz. parentral, oral, transdermal, nasal, pulmonary, rectal, buccal and ocular drug delivery systems. There are many reviews on various delivery strategies for protein and peptide pharmaceuticals, but the present review article provides a bird's eye view on various
novel drug delivery systems used for enhanced delivery of protein and peptide pharmaceuticals in the light of patent literature. Apart from this, the present manuscript endeavor provides idea on possible causes and major degradation pathways responsible for poor stability of protein and peptide
drugs along with recent market instances on them utilizing novel drug delivery systems.",
}