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Recent Achievements on Siderophore Production and Application

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Iron is the most abundant chemical element on Earth but its most common oxidation state is Fe(III) which presents a very low solubility under physiological conditions. During evolution, micro-organisms have developed sound strategies to acquire iron from both the environment and superior organisms, including direct uptake of iron ions from exogenous iron/heme sources and the synthesis of specialized Fe(III) chelators called siderophores. The present review paper aims at presenting and discussing the latest achievements in siderophore isolation and production, as well as novel applications of these molecules in therapies against iron-related diseases and in vaccines, and their application as antimicrobial agents and biosensors.

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Keywords: Antibacteria; Neurodegenerative diseases; Pathogen competition; Pyoverdin; Siderophore; antifungal; antimicrobial; biosensor; catecholate; chelation therapy; hydroxamate; iron chelation; iron homeostasis; iron overload; synthesis; vaccines

Document Type: Research Article

Publication date: December 1, 2011

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  • Recent Patents on Biotechnology publishes review articles by experts on recent patents on biotechnology. A selection of important and recent patents on biotechnology is also included in the journal. The journal is essential reading for all researchers involved in all fields of biotechnology.
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