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Polyfunctional Antibiotics Affecting Bacterial Membrane Dynamics

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The β-lactam family of antibiotics, the penicillins and cephalosporins, act primarily at the level of the bacterial membrane by inhibiting membrane proteins associated with cell wall synthesis. As a family they represent some of the most clinically relevant antibiotics known, although antibiotic resistance has limited the use of older generation β-lactams, novel compounds are currently emerging from research efforts worldwide. Fortuitously, there are other families of antibiotics of peptide-derived origin and possessing polyfunctional chemical groups-compounds with complex and multiple pharmacophores with biological function- that also act at the level of the bacterial membrane. Polyfunctional antibiotics interfere with bacterial growth by direct interaction with the cell membrane lipid bilayer and its constitutive array of metabolically active enzymes and structural proteins.

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Keywords: Bacterial Membrane; cell membrane; cephalosporins; enzymes; lipid; penicillins; pharmacophores; β-lactam family

Document Type: Research Article

Publication date: January 1, 2009

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  • Anti-Infective Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new anti-infective agents.
    Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in anti-infective medicinal chemistry.

    Anti-Infective Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in anti-infective drug discovery.
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