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Developing Phytoestrogens for Breast Cancer Prevention

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Breast cancer is one of the most common types of cancer in women, and is the second leading cause of cancer-related deaths in the United States. Chemoprevention using phytoestrogens (PEs) for breast cancer may be a valid strategy. PEs are phytochemicals with estrogen-like structures and can be classified into four types: isoflavones, lignans, stilbenes and coumestans. They are widely distributed in diet and herbs and have shown anti-cancer activity via mechanisms including estrogen receptor modulation, aromatase inhibition, and anti-angiogenesis. Genistein, daidzein and resveratrol are some of the most studied PE examples. Quality control in product manufacturing and clinical study design is a critical issue in developing them as clinically effective chemopreventive agents for breast cancer.
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Keywords: Aromatase inhibitor; Breast cancer; Chemoprevention; Coumestrol; Daidzein; Enterodiol; Enterolactone; Equol; Estrogen receptor modulator; Genistein; Glycitein; Matairesinol; Phytoestrogens; Resveratrol; Secoisolariciresinol; Sesamin

Document Type: Research Article

Publication date: December 1, 2012

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