Skip to main content
padlock icon - secure page this page is secure

Modulation of Histone Acetylation by Garlic Sulfur Compounds

Buy Article:

$68.00 + tax (Refund Policy)

Preclinical studies have shown that fresh garlic extracts, aged garlic, garlic oil and specific organosulfur compounds generated by processing garlic could alter carcinogen metabolism, inhibit tumor cell growth through induction of cell cycle arrest or apoptosis, or angiogenesis. In particular, recent studies have suggested that anticarcinogenic effects of certain garlic compounds may implicate at least in part a modulation of histone acetylation, a process involved in the regulation of gene expression, resulting from the inhibition of histone deacetylase activity. The aim of this review is to describe the available data on sulfur compounds from garlic and histone acetylation and to discuss their potential for cancer prevention. Available data indicate that garlic compounds could inhibit histone deacetylase activity and induce histone hyperacetylation both in vitro as well as in vivo. Sparse studies provide evidence of involvement of histone acetylation in modulation of gene expression by diallyl disulfide and allyl mercaptan. These effects were observed at high concentrations. Further investigations are needed to determine if the HDAC inhibitory effects of garlic organosulfur compounds play a role in primary cancer prevention at doses achievable by human diet.





No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: 3T3-L1 cells; CDKN1A gene; Garlic; HDAC activity; HDACIs; Tumoral Tissues; [3H]thymidine; allyl mercaptan; cancer prevention; diallyl disulfide; gene expression; histone acetylation; histone deacetylase activity; hyperacetylation; sulfur compounds

Document Type: Research Article

Publication date: March 1, 2011

More about this publication?
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more