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S3I-201, a Novel STAT3 Inhibitor, Inhibits Growth of Human Soft Tissue Sarcoma Cell Lines

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Background: STAT3 has been identified as a novel target to treat and prevent cancers with a broad potential application. Aim: To investigate whether constitutive STAT3 plays a role in the survival and growth of soft tissue sarcoma (STS) cell lines. Materials and Methods: Expression and activity of STAT3 were characterized by Western blot and Immunohistochemistry staining. S3I-201 in different doses or vehicle was added into cell culture respectively. Cell growth and colony formation were determined using crystal violet colorimetric and clonogenic assays. Results: Western blot demonstrated 5 out of 6 STS cell lines expressed constitutively activated STAT3. STAT3 inhibitor S3I-201 mono-therapy induced anti-proliferative effects on majority of STS cell lines harboring aberrant STAT3 by blocking STAT3 phosphorylation. Conclusion: Our study demonstrated that a high level of STAT3 phosphorylation is present in the human STS cell lines that we examined. Furthermore targeting STAT3 is a potential novel approach to pursue in anti-sarcoma therapy.
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Document Type: Research Article

Publication date: April 1, 2013

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  • World Journal of Cancer Research publishes original articles describing significant new findings in any area related to basic and clinical cancer research. These include studies of cancer related genes, molecules, drugs, cancer cell lines, tumorigenesis, cancer prevention, cancer progression and metastasis, cancer diagnosis, cancer treatment, cancer animal models, human cancer samples as well as cancer patients and all other cancer research related areas.
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