New low-noise detection method has been developed and used for design of a new type of biosensors based on detection of nano-sized superparamagnetic particles or magnetic beads that serve as labels for biochemical reactions. The method is based on non-linear magnetization of such particles. The particles are exposed to a magnetic field having components at two frequencies f 1 and f 2. The response is measured at combinatorial frequencies f i = m · f 1 + n · f 2, where m and n are integers (one of them can be zero). The integers can be varied to get the best signal-to-noise ratio, e.g., f i = f 1 ±2 · f 2. Several readers have been designed for the particles counting and used for different immunoassay formats, including those compatible with immunoconcentration and magnetic enrichment of antigens. Registration of 0.1 ng/ml of Y. pestis antigen and 103 cell/ml of Salmonella typhimurium has been demonstrated. The developed biosensing platforms can be used for medical diagnostics, points of care, food pathogen detection, water analysis, etc.
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Document Type: Research Article
Publication date: 01 March 2007
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