@article {Zhang:2020:1947-2935:93,
title = "Synthesis of Baicalein Modified Cerium Oxide Nanoparticles for Inhibitory Activation of NF-B and Mitogen-Activated Protein Kinase Signals in Rotenone-Induced Parkinsonian Rats",
journal = "Science of Advanced Materials",
parent_itemid = "infobike://asp/sam",
publishercode ="asp",
year = "2020",
volume = "12",
number = "1",
publication date ="2020-01-01T00:00:00",
pages = "93-100",
itemtype = "ARTICLE",
issn = "1947-2935",
url = "https://www.ingentaconnect.com/content/asp/sam/2020/00000012/00000001/art00011",
doi = "doi:10.1166/sam.2020.3594",
keyword = "BAICALEIN, PARKINSON'S DISEASE, CERIUM OXIDE NPS, MAPK, NF-κB",
author = "Zhang, Zhuang and Zhong, Meng and Wang, Jun and Xia, Dongjian and Bao, Jinsuo",
abstract = "Baicalein is one of the chief flavones extracted from Scutellariabaicalensis georgi which was earlier reported for its neuroprotective efficacy against Parkinson's disease (PD). In the present study, a simple and efficient synthetic procedure for the preparation of CeO2NPs
using Ce(NO3)3 as a primary precursor and baicalein as a stabilizing agent was proposed. Further, the neuroprotective response of baicalein stabilized CeO2 NPs against rotenone-stimulated parkinsonian diseased mice has been explored both in-vitro and
in-vivo. From the experimental findings, it was also evident that baicalein exposure has enhanced the motor impairments, and hindered the pro-inflammatory cytokine release and blocked the NF-B along with MAPK signaling pathway in rotenone-stimulated PD rat models.",
}