@article {Zhu:2019:1947-2935:1353,
title = "Preparation of pH-Responsive Hydroxyapatite-Encapsulated Magnetic Fe3O4 Composite Materials with Sandwich Construction for Drug Delivery of Doxorubicin",
journal = "Science of Advanced Materials",
parent_itemid = "infobike://asp/sam",
publishercode ="asp",
year = "2019",
volume = "11",
number = "10",
publication date ="2019-10-01T00:00:00",
pages = "1353-1361",
itemtype = "ARTICLE",
issn = "1947-2935",
url = "https://www.ingentaconnect.com/content/asp/sam/2019/00000011/00000010/art00002",
doi = "doi:10.1166/sam.2019.3417",
keyword = "MAGNETIC FE3O4, PH-RESPONSIVE HYDROXYAPATITE-ENCAPSULATED, DELIVERY OF DOXORUBICIN",
author = "Zhu, Hao and Chen, Jian and Huang, Fangzhi and Ji, Yang and Zhang, Li",
abstract = "Novel dandelion-flower-like composite materials containing a hydroxyapatite (HAP) micro-scaffold, SiO2-coated Fe3O4 magnetite nanoparticles and a thin HAP shell have been successfully synthesized and evaluated as micro-carriers of doxorubicin (DOX) for
cancer therapy. The scaffold, a peony-flower-like HAP crystalline, displays hierarchical structure and large surface-area-to-volume ratio to increase the drug payload. The outer HAP layer exhibits to improve the serum stability of drug delivery system. Due to the design of sandwich construction,
HAP plays a pivotal dual role not only in acting as a drug depot, but also in rendering the drug release rate with a highly pH-dependent controlled manner. DOX release from HAP/Fe3O4@SiO2/DOX/HAP composite was efficiently inhibited at physiological pH (pH 7.4),
while was facilitated at an endosomal pH (pH 4.5). The anti-cancer efficacy toward HeLa cells was also evaluated, exhibiting its potential as candidate for practical application in drug-delivery for therapeutic approaches.",
}