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Non-Biofouling Fluorinated Block Copolymer Coatings for Contact Lenses

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Films of two fluorinated block copolymers (P(S81-Sz6) and P(S81-Sz11)) were investigated and compared with those of a commercial Teflon-like polymer (PTFE-AF) in the search for novel non-biofouling coatings able to minimize the amount of tear fluid (TF) proteins absorbed on contact lens (CL) surfaces. The adsorption of a solution containing lysozyme, albumin and immunoglobulin G (mimicking the TF composition) on the fluorinated block copolymers was evaluated using a quartz crystal microbalance. P(S81-Sz11) was found to resist protein adsorption more effectively than P(S81-Sz6) and PTFE-AF. The different interaction of P(S81-Sz6) and P(S81-Sz11) with the artificial TF was attributed to creation of a more heterogeneous and moderately hydrophobic surface of the latter polymer film by dynamic contact angle and atomic force microscopy studies. Moreover, deposition of P(S81-Sz11) on a CL-like silicone (PDMS) and a CL thin films demonstrated a protein adsorption reduction of up to 70% relative to pristine PDMS and commercial CL thin films.
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Keywords: ATOMIC FORCE MICROSCOPY; CONTACT ANGLE; CONTACT LENSES; PROTEIN ADSORPTION; QUARTZ CRYSTAL MICROBALANCE

Document Type: Research Article

Publication date: July 1, 2015

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  • Science of Advanced Materials (SAM) is an interdisciplinary peer-reviewed journal consolidating research activities in all aspects of advanced materials in the fields of science, engineering and medicine into a single and unique reference source. SAM provides the means for materials scientists, chemists, physicists, biologists, engineers, ceramicists, metallurgists, theoreticians and technocrats to publish original research articles as reviews with author's photo and short biography, full research articles and communications of important new scientific and technological findings, encompassing the fundamental and applied research in all latest aspects of advanced materials.
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