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Carbon Nanotube Assisted Drug Delivery of Donepezil and Its Derivatives as Acetylcholinesterase Enzyme (AChE) Inhibitors

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Alzheimers's disease estimates 60%–70% of dementia characterized mostly by short-term memory loss. The cause of the disease is not properly known and many scientists target for inhibiting the acetylcholinesterase enzyme (AChE) because this enzyme plays an important role in breaking down acetylcholine. So far Donepezil has been approved in the market as acetylcholinesterase inhibitor which has bioavailability problems and hence urgent requirement for new therapies. The present investigation aims on the molecular docking studies and its subsequent thermodynamic energy calculation on the protein-ligand interaction of Donepezil and three other generic compounds having 99% similarity with Donepezil conjugated with (5, 5) armchair. The used of the functionalized CNT as a drug delivery system improves the pharmacological and therapeutic profile of the investigated compounds thereby overcoming its bioavailability behavior. Also, the result from the molecular docking studies based on thermodynamics and energy terms pictured the feasibility of carbon nanotube as nano-carrier in loading and delivering Donepezil and its derivatives at the specific active site of AChE.
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Keywords: ACETYLCHOLINESTERASE; ALZHEIMERS'S DISEASE; CARBON NANOTUBE; DONEPEZIL

Document Type: Research Article

Publication date: 01 December 2015

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  • Nanomedicine and Nanobiology (NMB) is a multidisciplinary, peer-reviewed international journal covering the most important scientific fields of the twenty-first century- nanotechnology for medical applications. The core research areas within the scope of this journal include: nanoscale drugs and drug delivery systems; diagnosis, monitoring, prediction, therapy, prevention, and treatment of various types of cancer and other diseases; pharmaceutics, pharmacokinetic behavior, pharmacodynamics, safety and toxicology of biomedicine, molecular therapy, regenerative medicine, biomedical imaging technologies, and structural nanobiology.
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