Electrochemical impedance spectroscopy study of electroactive poly(ε-caprolactone)/polypyrrole (PCL/PPy) electrospun nanofibers which are functionalized with single-stranded DNA (ssDNA) were performed for the first time. PCL nanofibers which have high loading capacity for
bioactive molecules were fabricated by electrospinning. ssDNA were immobilized onto PCL/PPy nanofibers following to pyrrole (Py) polymerization on electrospun PCL nanofibers. Electrochemical impedance spectroscopy (EIS) and equivalent electrical circuit modeling was used to investigate the
changes in interfacial electrical properties of PCL/PPy nanofibers that arise from ssDNA immobilization, and hybridization with complementary and non-complementary DNA sequences. The surface morphology of the DNA immobilized PCL/PPy nanofibers become rough and the fiber diameters were increased.
Elemental analyses and EDX-mapping showed that the ssDNA was evenly distributed on the surface of the nanofibers. Charge transfer resistance (Rct) of ssDNA/PPy/PCL nanofibers were decreased with the increasing concentrations of immobilized DNA. After hybridization with fully complementary
DNA, significant decreased in charge transfer resistance and solution resistance was observed due to change of surface charge of nanofibers and conformation of DNA during the hybridization process. PCL/PPy nanofiber mats were found to be promising materials which would be used in electrochemical
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ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY (EIS);
SCANNING ELECTRON MICROSCOPY/ENERGY-DISPERSIVE X-RAY SPECTROSCOPY (SEM/EDX)
Document Type: Research Article
August 1, 2015
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Materials Express is a peer-reviewed multidisciplinary journal reporting emerging researches on materials science, engineering, technology and biology. Cutting-edge researches on the synthesis, characterization, properties, and applications of a very wide range of materials are covered for broad readership; from physical sciences to life sciences. In particular, the journal aims to report advanced materials with interesting electronic, magnetic, optical, mechanical and catalytic properties for industrial applications.
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