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The Importance of Nutritional Factors on Human Male Fertility: A Toxicological Approach

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Infertility is a multifactorial phenomenon causing concern to many couples. Among the various determinants that affect positively or negatively human male fertility particular attention has been paid to factors—directly or indirectly-related in nutrition, although the published studies present conflicting results. The purpose of this study is the systematic review (grouping and analysis) of the literature via the online databases Google Scholar and PubMed between 1990 and 2012. The results seem to suggest that: (a) most of the nutritional supplements that have shown some positive results in vitro-alone or in combinations-have not been proven to lead to a cure, but rather when they are over-consumed could be toxic (b) despite the fact that infertility is not always motivated by poor nutrition or harmful lifestyle factors, a combined change in eating patterns and lifestyle can usually increase the possibility of fertilization, especially when other medical causes for infertility are absent. Regarding the evaluation of the action of individual food ingredients or combinations, additional double-blind, randomized, controlled clinical studies are expected to provide key answers in the future.


Document Type: Editorial

Publication date: March 1, 2014

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  • Journal of Translational Toxicology is an international peer-reviewed journal, publishes original research articles, short communications, case reports and reviews dealing with all aspects of toxicology including in vitro, in vivo and mechanistic toxicology, human biomonitoring and environmental risk assessment, biochemical and molecular effects of drugs/toxicants, development of biomarkers for monitoring the drug/toxicant induced injury, in silico approaches for predictive toxicity testing, innovative methods and approaches in risk assessment, sensors, devices and chips for detection of biomolecules, toxicants and contaminants, nanomedicine, nanotoxicology, and much more.
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