Skip to main content
padlock icon - secure page this page is secure

Development and Characterization of Nanostructured Lipid Carriers of Vetiveria zizanoides Oil for Therapeutic Potential in Prickly Heat Treatment

Buy Article:

$106.34 + tax (Refund Policy)

Vetiveria zizanoides oil (vetiver oil) and Azadirachta indica seed oil (neem oil) are both known for their medicinal value since ancient times. The present study is aimed to formulate stable nanostructured lipid carrier (NLC) using vetiver oil and lipids (glyceryl monostearate and neem oil) as solid and liquid lipid by melt-emulsification and ultrasonication method. The NLCs were formulated so as to entrap oil into solid lipid core giving a controlled release. NLCs were formulated applying factorial design, using solid and liquid lipids in varying ratios 60:40 to 90:10. NLCs were evaluated for physiochemical properties and in vitro release. The optimized NLC formulation was incorporated into carbopol gel and was further investigated for permeation studies using goat skin, irritation studies employing HET CAM technique and antimicrobial activity. The ratio 70:30 produced the most stable formulation. The optimized NLC showed least particle size (296.9 nm), showed highest entrapment efficiency (92.7%) and prolonged drug release (85.97%) over a period of 36 hours. The optimized NLCs gel showed no sign of skin irritation, displayed good dermal retention (>60%) as well as significant antimicrobial activity as compared to vetiver oil alone and placebo gel. The NLC based gel of vetiver oil can be a promising formulation for prickly heat treatment.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics


Document Type: Research Article

Publication date: June 1, 2015

More about this publication?
  • Journal of Pharmaceutical Sciences and Pharmacology is being launched to address the disconnect among different research areas related to pharmaceutical sciences and pharmacology. The extreme specialization has resulted in compartmentalization and complete segregation of disciplines related to pharmaceutical sciences. Relating a new development in drug delivery has become difficult to be noticed by the researchers in other related disciplines like the pharmacologists and/or clinicians. The aim of this journal is to publish high quality original research work and broad reviews in all related disciplines relevant to drugs under the same umbrella. Our expectation is that it will help the researchers, scholars and scientists to put their and others' work in the bigger context resulting in enhanced interdisciplinary and integrated research effort. The journal is intended to cover all disciplines and challenges in science, technology and engineering that contribute to the development of new improved drug molecules and their uses including pharmaceutical aspects.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more