Development and Characterization of Nanostructured Lipid Carriers of Vetiveria zizanoides Oil for Therapeutic Potential in Prickly Heat Treatment
Vetiveria zizanoides oil (vetiver oil) and Azadirachta indica seed oil (neem oil) are both known for their medicinal value since ancient times. The present study is aimed to formulate stable nanostructured lipid carrier (NLC) using vetiver oil and lipids (glyceryl monostearate and neem oil) as solid and liquid lipid by melt-emulsification and ultrasonication method. The NLCs were formulated so as to entrap oil into solid lipid core giving a controlled release. NLCs were formulated applying factorial design, using solid and liquid lipids in varying ratios 60:40 to 90:10. NLCs were evaluated for physiochemical properties and in vitro release. The optimized NLC formulation was incorporated into carbopol gel and was further investigated for permeation studies using goat skin, irritation studies employing HET CAM technique and antimicrobial activity. The ratio 70:30 produced the most stable formulation. The optimized NLC showed least particle size (296.9 nm), showed highest entrapment efficiency (92.7%) and prolonged drug release (85.97%) over a period of 36 hours. The optimized NLCs gel showed no sign of skin irritation, displayed good dermal retention (>60%) as well as significant antimicrobial activity as compared to vetiver oil alone and placebo gel. The NLC based gel of vetiver oil can be a promising formulation for prickly heat treatment.
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Document Type: Research Article
Publication date: 01 June 2015
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