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Design, In Vitro and In Vivo Evaluation of Fluconazole Bioadhesive Vaginal Tablets

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Fluconazole is a synthetic triazole antifungal drug. It is available as tablets, capsules, oral suspension and injection for treatment of oral, esophageal and vaginal candidiasis. The present work was envisaged to develop a novel and aesthetic bioadhesive vaginal delivery system with improved efficacy. The compatibility between the drug, mucoadhesive polymers and tablet excipients (carbopol, HPMC, Xanthan gum and EC) was studied using Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimeter (DSC). Fluconazole bioadhesive vaginal tablets (FBVTs) were prepared using mixtures of polymers that gave the optimal physico-mechanical properties and also showed the most delayed in-vitro release results. The in-vitro susceptibility profile of Candida albicans to Fluconazole was evaluated using agar cup method. The inhibition zones were calculated and these values were taken as the antifungal effect of the drug. The bioadhesive tablets were clinically evaluated in volunteers suffering from vaginal candidiasis and compared with commercial Fluconazole vaginal tablets (Diflucan® 150 mg).
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Document Type: Research Article

Publication date: June 1, 2015

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  • Journal of Pharmaceutical Sciences and Pharmacology is being launched to address the disconnect among different research areas related to pharmaceutical sciences and pharmacology. The extreme specialization has resulted in compartmentalization and complete segregation of disciplines related to pharmaceutical sciences. Relating a new development in drug delivery has become difficult to be noticed by the researchers in other related disciplines like the pharmacologists and/or clinicians. The aim of this journal is to publish high quality original research work and broad reviews in all related disciplines relevant to drugs under the same umbrella. Our expectation is that it will help the researchers, scholars and scientists to put their and others' work in the bigger context resulting in enhanced interdisciplinary and integrated research effort. The journal is intended to cover all disciplines and challenges in science, technology and engineering that contribute to the development of new improved drug molecules and their uses including pharmaceutical aspects.
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