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Novel Mn-SOD Mimetics Offer Superior Protection Against Oxidative Damages in Hek293 Kidney Cells

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A series of ternary Mn (II) complexes have been synthesized employing combination of thiosemicarbazones as primary ligand and bipyridyl/aminoethanethiol as ancillary ligands and structurally characterized. The compounds were examined for their protective effects in Xanthine–Xanthine oxidase-induced oxidative stress in HEK-293 kidney cells using MTT assay, confocal imaging and Western blots. All compounds offer protection against the oxidative stress generated by Xanthine–Xanthine oxidase system, while compounds having aminoethanethiol as ancillary ligands especially exhibit potent effects even at nanomolar concentrations. These compounds seem to operate mechanistically through quenching of ROS and enhancing Mn-SOD expression in mitochondria.


Document Type: Research Article

Publication date: June 1, 2014

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  • Journal of Pharmaceutical Sciences and Pharmacology is being launched to address the disconnect among different research areas related to pharmaceutical sciences and pharmacology. The extreme specialization has resulted in compartmentalization and complete segregation of disciplines related to pharmaceutical sciences. Relating a new development in drug delivery has become difficult to be noticed by the researchers in other related disciplines like the pharmacologists and/or clinicians. The aim of this journal is to publish high quality original research work and broad reviews in all related disciplines relevant to drugs under the same umbrella. Our expectation is that it will help the researchers, scholars and scientists to put their and others' work in the bigger context resulting in enhanced interdisciplinary and integrated research effort. The journal is intended to cover all disciplines and challenges in science, technology and engineering that contribute to the development of new improved drug molecules and their uses including pharmaceutical aspects.
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