Impact of Commonly Used Antidiabetic Drugs on Collagen Metabolites
The objective of this research work is to investigate the effect of commonly used antidiabetic drugs such as Repaglinide, Pioglitazone, Glipizide and Metformin on collagen metabolites in healthy wistar albino rats. In this study 25% reduction in the activity of cathepsin D was observed in pioglitazone drug administered group when compared to control group. There was no change in the protein content and acid phosphatase enzyme level in the organs studied. Glycosaminoglycans (GAGs), hexosamine, and uronic acid content in the skin of animals treated with antidiabetic drugs showed significant changes (P < 0 01,P < 0 001) when compared to control group. The stress strain characteristics of the skin in normal and drug treated animals remain unaltered. The nativity (triple helical structure) of collagen is supported by Differential Scanning Calorimetry (DSC). Circular Dichroism (CD) study showed the intensity of positive and negative amide bands of collagen. The present study concludes the effect of antidiabetic drugs on collagen and its metabolites in wistar rats and this knowledge is useful and unique in the treatment of aging disease like diabetes.
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Document Type: Research Article
Publication date: 01 March 2014
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