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Anti-inflammatory Effect of Euphorbia hirta Leaf Extract in Rats and Modulation of Inflammation-Associated Prostaglandins (PGE-2) and Nitric Oxide (NO) Expression in RAW264.7 Macrophage

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Euphorbia hirta L. (Euphorbiaceae) is a traditional herbal medicine and known to reduce the risk of many diseases. In this study, we evaluated the anti-inflammatory effect of E. hirtaleaves methanol extract (EhME) on RAW246.7 macrophage pro-inflammatory cytokines production and correlated with in vivoinflammatory paw oedema model. EhME inhibited the cyclooxygenase (COX) mediated prostagladins E-2 (PGE-2) and nitric oxide synthsae (NOS) catalyzed nitric oxide (NO) production in LPS-induced marophages. Anti-inflammatory effect of EhME accompanied by the reduced produc- tion of pro-inflammatory cytokines including TNF-α, IL-6 and IL-1β in a dose-dependent manner. In vivoevaluation in carrageenan-induced wistar rat paw oedema, correlated with in vitroanti-inflammatory findings of EhME, as 500 mg/kg b. w. concentration possess anti-inflammatory effect comparable to reference non-steroidal diclofenac (10 mg/kg b. w.). Our data showed and correlated the in vitro– in vivoanti-inflammatory property of EhME.
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Keywords: CARRAGEENAN; CYCLOOXYGENASE; EUPHORBIA HIRTA L; RAW246.7 MACROPHAGES

Document Type: Research Article

Publication date: 01 March 2014

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  • Journal of Pharmaceutical Sciences and Pharmacology is being launched to address the disconnect among different research areas related to pharmaceutical sciences and pharmacology. The extreme specialization has resulted in compartmentalization and complete segregation of disciplines related to pharmaceutical sciences. Relating a new development in drug delivery has become difficult to be noticed by the researchers in other related disciplines like the pharmacologists and/or clinicians. The aim of this journal is to publish high quality original research work and broad reviews in all related disciplines relevant to drugs under the same umbrella. Our expectation is that it will help the researchers, scholars and scientists to put their and others' work in the bigger context resulting in enhanced interdisciplinary and integrated research effort. The journal is intended to cover all disciplines and challenges in science, technology and engineering that contribute to the development of new improved drug molecules and their uses including pharmaceutical aspects.
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