Anti-inflammatory Effect of Euphorbia hirta Leaf Extract in Rats and Modulation of Inflammation-Associated Prostaglandins (PGE-2) and Nitric Oxide (NO) Expression in RAW264.7 Macrophage
Euphorbia hirta L. (Euphorbiaceae) is a traditional herbal medicine and known to reduce the risk of many diseases. In this study, we evaluated the anti-inflammatory effect of E. hirtaleaves methanol extract (EhME) on RAW246.7 macrophage pro-inflammatory cytokines production and correlated with in vivoinflammatory paw oedema model. EhME inhibited the cyclooxygenase (COX) mediated prostagladins E-2 (PGE-2) and nitric oxide synthsae (NOS) catalyzed nitric oxide (NO) production in LPS-induced marophages. Anti-inflammatory effect of EhME accompanied by the reduced produc- tion of pro-inflammatory cytokines including TNF-α, IL-6 and IL-1β in a dose-dependent manner. In vivoevaluation in carrageenan-induced wistar rat paw oedema, correlated with in vitroanti-inflammatory findings of EhME, as 500 mg/kg b. w. concentration possess anti-inflammatory effect comparable to reference non-steroidal diclofenac (10 mg/kg b. w.). Our data showed and correlated the in vitro– in vivoanti-inflammatory property of EhME.
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Document Type: Research Article
Publication date: 01 March 2014
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