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Conditioned Medium of Human Immortalized Mesenchymal Stem Cells as a Novel Therapeutic Tool to Repair Damaged Tissues

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Transplantation of mesenchymal stem cells (MSCs) has become available for repairing tissue damage. Recent studies demonstrated that MSC-derived conditioned medium (CM) also can repair tissue damage. To maintain MSCs and CM of excellent quality in a long-term cell culture, we developed clones of immortalized MSCs (iMSCs) from human dental pulp-derived primary MSCs. Each clone of iMSCs produced constant amounts of bioactive molecules. Using gene expression microarrays and antibody arrays, we found that the iMSCs generate and secrete a broad spectrum of bioactive molecules, some of which are immunoregulatory and others modify microenvironments to promote tissue regeneration. The CM of iMSCs (iMSC-CM) is suitable for mass production and mass distribution, and offers safe and efficient therapeutic strategies to treat various diseases. Using iMSC-CM we have initiated clinical studies to treat diabetes and liver cirrhosis. We also have a keen interest in treating neurological disorders using iMSC-CM obtained from human dental pulp-derived MSCs, which have unique characteristics to differentiate into neural cells.


Document Type: Research Article

Publication date: June 1, 2017

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  • Journal of Neuroscience and Neuroengineering (JNSNE) is an international peer- reviewed journal that covers all aspects of neuroscience and neuroengineering. The journal publishes original full-length research papers, letters, tutorials and review papers in all interdisciplinary disciplines that bridge the gaps between neuroscience, neuroengineering, neurotechnology, neurobiology, brain disorders and diseases, novel medicine, neurotoxicology, biomedical engineering and nanotechnology.
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