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Physiological Mapping of Brain Functions In Vivo: Surface Monitoring of Hemodynamic Metabolic Ionic and Electrical Activities in Real-Time

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Normal brain activity is an integration of many biochemical and physiological processes including hemodynamic, metabolic, ionic homeostasis and electrical activities. In order to evaluate the functional state of the brain, it is necessary to monitor in real time as many parameters as possible. We developed the concept of "Brain Physiological Mapping" that describes the interrelations between the various parameters measured by the multiparametric monitoring system. We used these systems in experimental animal models as well as in neurosurgical patients. The monitored brains were exposed to pathophysiological conditions including changes in oxygen supply (hypoxia, ischemia or hyperoxia) or in the level of activity (epilepsy or cortical spreading depression). The key monitored parameter, in all monitoring systems, was the oxidation-reduction state of NADH, representing the mitochondrial function. This parameter provided information on oxygen supply as well as oxygen balance in the brain. In the current review, the various systems developed, by our group since 1972 are presented including a typical record of the results obtained.
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Keywords: BRAIN ENERGY METABOLISM; BRAIN IONS HOMEOSTASIS; BRAIN OXYGEN BALANCE; CEREBRAL BLOOD FLOW; CORTICAL SPREADING DEPRESSION; ELECTROCORTICOGRAPHY; INTRACRANIAL PRESSURE; MITOCHONDRIAL FUNCTION

Document Type: Review Article

Publication date: April 1, 2013

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  • Journal of Neuroscience and Neuroengineering (JNSNE) is an international peer- reviewed journal that covers all aspects of neuroscience and neuroengineering. The journal publishes original full-length research papers, letters, tutorials and review papers in all interdisciplinary disciplines that bridge the gaps between neuroscience, neuroengineering, neurotechnology, neurobiology, brain disorders and diseases, novel medicine, neurotoxicology, biomedical engineering and nanotechnology.
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