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TiO2-Chitosan Hybrid Materials for Drug Delivery Applications: Conjugation Reaction with a Model Drug and Evaluation of the Functional Properties

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The combination of TiO2 and chitosan is known to allow the achievement of implantable devices which combines the mechanical properties of TiO2, with the presence of chitosan, which ensures antibacterial properties combined with an in-situ drug-delivery of biomolecules physisorbed and/or covalently linked to chitosan. In this study, 5-aminofluorescein (5-AF), a derivative of fluorescein containing a primary amino group, has been used as model molecule to simulate a drug. This dye is characterized by low cost and low toxicity, and due to its high molar absorptivity it can easily be detected by means of absorption and emission spectroscopies. The combination of 5-AF and maleic anhydride (MA) with TiO2-chitosan materials has generated a range of novel hybrid materials tailored to applications in localized stimuli-responsive drug delivery systems. Maleic anhydride has been used as pH sensitive spacer for the covalent functionalization of the TiO2-chitosan hybrid with MA as linker molecule. This functionalization allowed to obtain a pH-sensitive hybrid material. The efficiency of the functionalization has been verified by means of different physico-chemical characterization techniques. The behaviour of the functionalized materials is related to different parameters, among which the ratio between physisorbed/coordinated and chemisorbed 5-AF and the matrix degradation. Moreover, delivery tests in simulated body solutions at different pH have been performed showing a pH-sensitive drug delivery behaviour and indicating that the release of 5-AF is favoured at basic pH.

Keywords: Implantable Device; Post-Synthesis Covalent Functionalization; Release Kinetics Tests in Buffered Solution at Different pH; TiO2-Chitosan Hybrid; pH-Sensitive Drug Delivery System

Document Type: Research Article

Affiliations: 1: Dipartimento di Chimica & Centro Interdipartimentale NIS (Nanostructured Interfaces and Surfaces) Università di Torino & Consorzio Interuniversitario Nazionale per la Scienza a la Tecnologia dei Materiali-Unità di Ricerca di Torino, via P. Giuria 7, 10125 Torino, Italy 2: Dipartimento di Chimica & Centro Interdipartimentale NIS (Nanostructured Interfaces and Surfaces) Università di Torino & Consorzio Interuniversitario Nazionale per la Scienza a la Tecnologia dei Materiali-Unità di Ricerca di Torino, via P. Giuria 7, 10125 Torino, Italy 3: Dipartimento di Scienze Molecolari e Nanosistemi, Università Ca’ Foscari Venezia & Consorzio Interuniversitario Nazionale per la Scienza a la Tecnologia dei Materiali-Unità di Ricerca di Venezia, via Torino 155, 30172 Mestre Venezi, Italy

Publication date: May 1, 2021

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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