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Home / Journal of Nanoscience and Nanotechnology, Volume 21, Number 1

Selective Loading and Prolonged Release of 5-Fluorouracil in the Nanoconfined Interlayer Space of Montmorillonite

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Montmorillonite was used as a carrier for the anticancer drug 5-fluorouracil (5FU). The selective loading of 5FU into the nanoconfined interlayer space of montmorillonite was achieved by rinsing off the weakly bonded 5FU from the external surface. The 5FU loading content in montmorillonite was 3.2 mass%. The intercalated 5FU was in an amorphous state and might be arranged as a roughly vertical monolayer in the interlayer space of montmorillonite. The intercalated 5FU showed a high thermal stability due to the protection of the montmorillonite layers. The release profiles of the intercalated 5FU were well fitted with the modified Korsmeyer-Peppas model. The montmorillonite exhibited a prolonged release of 5FU due to the restriction of the outward diffusion of intercalated 5FU. The 5FU/montmorillonite system has promising potential for oral administration for colonspecific delivery.

Keywords: 5-Fluorouracil; Clay Mineral; Intercalation; Prolonged Release

Document Type: Research Article

Affiliations: 1: Key Laboratory of Solid Waste Treatment and Resource Recycle, Ministry of Education, School of Environment and Resource, Southwest University of Science and Technology, Sichuan Engineering Lab of Non-Metallic Mineral Powder Modification & High-Value Utilization, Mianyang 621010, China 2: Key Laboratory of Solid Waste Treatment and Resource Recycle, Ministry of Education, School of Environment and Resource, Southwest University of Science and Technology, Sichuan Engineering Lab of Non-Metallic Mineral Powder Modification & High-Value Utilization, Mianyang 621010, China 3: Department of Materials Science and Engineering, Michigan Technological University, Houghton, MI, 49931, USA

Publication date: 01 January 2021

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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