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Comparative Effectiveness of Surface Functionalized Poly-ε-Caprolactone Scaffold and β-TCP Mixed PCL Scaffold for Bone Regeneration

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Physio-chemical surface properties to biomaterial has been attention in tissue engineering due to their properties on cell adhesion, proliferation, and differentiation. The object of this study is to evaluate the preosteoblast biological response on physio-chemical surface-layered 3D PCL scaffold and 3D PCL/β-TCP scaffold. 3D scaffolds were fabricated by FDM 3D printing. Physio-chemical surface of 3D scaffolds were prepared by oxygen plasma and amine plasma-polymerization, respectively. The results of this study demonstrated that amine plasma-treated 3D scaffold on adhesion, proliferation, and osteogenic differentiation of the MC3T3-E1 was significantly increased compared to the other scaffolds.
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Keywords: 3D Scaffold; Functionalized Surface; Micro/Nano Surface; Osteoblast Behavior

Document Type: Research Article

Affiliations: 1: Suwan The Dental Hospital, 6, Suwan-ro, Gwangsan-gu, Gwangju, 62305, South Korea 2: School of Biomedical Engineering, Chonnam National University, 77, Yongbong-ro, Buk-gu, Gwangju, 61186, South Korea 3: Department of Oral and Maxillofacial Surgery, School of Dentistry, Chonnam National University, 77, Yongbong-ro, Buk-gu, Gwangju, 61186, South Korea

Publication date: 01 September 2020

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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